ABSTRACT
Background: Chronic hepatitis C is an important health problem in Chile. In 2005, the Ministry of Health started a pilot treatment program with peg interferon and ribavirin, to be developed in public hospitals all over the country. Aim: To report the results ofhepatitis C treatment obtained at our institution. Patients and Methods: Between 2005 and 2009, 63 patients were referred for treatment. In all, the viral load and genotype were determined. Peg interferon alpha-2a or alpha-2b plus ribavirin were used for therapy for up to 48 weeks in genotypes (G) 1 or 4 or 24 weeks in genotypes 2 or 3. If at the end oftreatment, viral load measured by polymerase chain reaction (PCR) was negative, it was repeated 6 months later. A negative viral load at that time was considered a sustained viral response (SVR). Results: Among the 51 patients who started treatment, 42 (80.4%) were G1,1 was G2,1 was G4 and 7 were G3. A SVR was reached in 51.1% ofG 1 and 4 and in 87.5% in G 3 and 2. In a univariate analysis, the variables significantly associated with a positive viral response were the degree offibrosis and body mass index. Conclusions: These results are similar to those obtained in other international series, demonstrating that Hispanic ethnicity does not influence the response to treatment. Our good results could be explained by the excellent compliance of the patients to the treatment. A higher degree offibrosis and a higher BMI were associated with a poor response.
Subject(s)
Female , Humans , Male , Middle Aged , Antiviral Agents/therapeutic use , Hepatitis C, Chronic/drug therapy , Interferon-alpha/therapeutic use , Ribavirin/therapeutic use , Antiviral Agents/adverse effects , Body Mass Index , Chile , Clinical Protocols/standards , Drug Therapy, Combination , Genotype , Hepatitis C, Chronic/pathology , Hepatitis C, Chronic/virology , Hospitals, Public , Interferon-alpha/adverse effects , Prospective Studies , Ribavirin/adverse effects , Treatment Outcome , Viral LoadABSTRACT
Se reporta un caso ilustrativo de un paciente de 77 años con lesión nodular pigmentada que apareció sobre una mácula color cafe de 15 años de evolución. La biopsia reporta melanoma maligno Clark IV, Breslow de 4mm. Se revisa el riesgo de trasformación del léntigo maligno a léntigo maligno melanoma
Subject(s)
Lentigo , MelanomaABSTRACT
Durante los años 1995 a 1999 fueron atendidos en el servicio de dermatología del CES en promedio 6870 pacientes por año, de los cuales el 70 por ciento de ellos fueron mujeres. La procedencia de los pacientes fue constante en los diferentes centros de atención siendo la mitad de los pacientes de Medellín y luego en su orden de Envigado, Itaguí, Sabaneta y otros municipios. Las primeras cinco causas de consultas fueron acné, melasma, verrugas, insuficiencia venosa y en quinto lugar otras como dermatitis atópica, psoriasis, nevus y carcinoma basocelular.